3/18/2023 0 Comments Increased blood viscosityThis study is the first to demonstrate blood hyper-viscosity and RBC hyper-aggregation in a large cohort of patients with COVID-19 and describe associations with enhanced coagulation and clinical outcomes.Ĭoronavirus disease 2019 (COVID-19) is an infectious disease characterized by fever, dry cough, anosmia, and dyspnea secondary to typical lung involvement. Patients with oxygen supplementation had higher RBC aggregation and blood viscosity than those without, and patients with pulmonary lesions had higher RBC aggregation and enhanced coagulation than those without. RBC aggregation correlated positively with clot firmness, negatively with clot formation time, and positively with the length of hospitalization. In-vitro experiments demonstrated a strong contribution of plasma fibrinogen in this RBC hyper-aggregation. Our study demonstrated that patients with COVID-19 had increased blood viscosity despite lower hematocrit than healthy individuals, as well as increased RBC aggregation. ![]() Rotational thromboelastography was performed in 76 patients to study clot formation dynamics. A control group of 38 healthy individuals was constituted to compare the blood rheological and RBC profile. Routine hematological/biochemical parameters, blood viscosity, RBC deformability and aggregation, and RBC senescence markers were measured on the first day of hospitalization. Clinical parameters were collected for each patient. A total of 172 patients with COVID-19, hospitalized in COVID-unit of the Internal Medicine Department (Lyon, France) participated in this study between January and May 2021. The aim of this study was to (1) analyze blood viscosity, red blood cell (RBC) deformability, and aggregation in hospitalized patients with Coronavirus disease 19 (COVID-19) (2) test the associations between impaired blood rheology and blood coagulation and (3) test the associations between impaired blood rheology and several indicators of clinical severity.
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